eFIEDTTR - Electronic Filatov Institute of Eye Diseases and Tissue Therapy Repository

Вітаємо в репозитарії ДУ «Інститут очних хвороб і тканинної терапії ім. В.П. Філатова НАМН України».

Відкритий електронний архів (репозитарій) eFIEDTTR забезпечує накопичення, систематизацію, зберігання та довготривалий, постійний і надійний безкоштовний відкритий доступ до інтелектуальних продуктів наукового, освітнього та навчально-методичного призначення, створених науковими та науково-педагогічними співробітниками, аспірантами Інституту імені В.П. Філатова.

Серед матеріалів репозитарія — статті з наукових журналів, матеріали конференцій, монографії, навчальні посібники, студентські роботи, дисертації та автореферати, презентації, звіти та ін.

Кількість документів у репозитарії: 1711

Електронний архів формується та функціонує відповідно до Положення про репозитарій Інститута імені В.П.Філатова.

Нові матеріали для розміщення надсилайте на filatovinstitut@ukr.net

У випадку виникнення питань з приводу публікації матеріалів, будь ласка, звертайтеся до бібліотеки Інститута імені В.П.Філатова або на електронну пошту filatovinstitut@ukr.net

Нові надходження

  • Тип елементу:Документ,
    Density of the photoreceptor in the macula according to adaptive optics in primary and secondary school children after a retinopathy of prematurity
    (2025) Насінник, Ілля Олегович; Щербакова, Валерія Володимирівна; Пєшкова, Анастасія Андріївна; Кацан , Сергій Володимирович; Пасєчнікова, Наталія Володимирівна; Король, Андрій Ростиславович
    Objectives: To determine the density of photoreceptors in the macula according to adaptive optics in secondary school children after a retino- phaty of prematurity Methods: Ophthalmoscopy with adaptive optics was performed in chil- dren using the RTX1 device (Imagine Eye, France). The inclusion criteria for the study were the age of children from 9 to 15 years, and retinopathy of prematurity in anamnesis, in which the pathological process regressed spontaneously. Depending on the gestational age ( GA) and body weight ( BW) at birth, children were divided into two groups. The first group in- cluded children, who were born very prematurely, 26–28 weeks G A and BW up to 1500 grams, the second group–those were born at 29–32 weeks GA and with BW up to 2500 grams. As a control, the studies were carried out in healthy children of the appropriate age. Photoreceptor density was assessed in the area of 4° from the center of the fovea in an area of 100 µm2 in each quadrant: superior temporal, superior nasal, inferior nasal and in- ferior temporal. During statistical analysis, the median of photoreceptor density by group and the level of significance of its difference were cal- culated. Results: 30 children (60 eyes) were examined. The study groups, matched for G A and B W, at the time of the study had a corrected visual acuity of 1.0 and the length of the anterior-posterior segment of the eye in the range from 22.2 to 23.7 mm. The first group included 10 deeply premature chil- dren (20 eyes), during the examination the photoreceptor density was 25063; the second group–10 premature children (20 eyes), the photore- ceptor density was 22308; in the control group were 10 full-term children (20 eyes), the photoreceptor density was 21222. However, in statistical analysis the difference was not significant. Conclusions: The density of retinal photoreceptors in our study did not differ statistically between premature children of primary and secondary school age with a self-regression of retinopathy of prematurity in anam- nesis and healthy children.
  • Тип елементу:Документ,
    Some mechanisms of the influence of polychromatic light on the condition of the cornea, lens and retina of rabbits in the experiment
    (2025) Коломійчук, Сергій Григорович
    The optical system of the eye consists of the cornea and the lens and forms a “refracton” for focusing the image on the retina. Studies of the biochemi- cal and biophysical mechanisms that ensure the transparency of this sys- tem indicate the importance of the spatial arrangement of collagen fibrils in the corneal stroma and crystallins in the cytoplasm of lens fiber cells. Post-translational modifications of proteins can lead to impaired transpar- ency and age-related cataracts (Quinlan RA, Clark JI., 2022). The structural and functional properties of eye tissues depend on metabolic processes that maintain homeostasis and adaptation of the visual analyzer to the action of pathogenic factors. One of the triggers for the development of pathological changes in eye tissues is oxidative and carbonyl stress dur- ing irradiation. Purpose: Determination of molecular mechanisms of the damaging effect of polychromatic light (P L) on the condition of the cornea, lens and retina of rabbits in the experiment. Material and Methods: Chinchilla rabbits (n = 12) were irradiated with high-intensity PL daily for 23 weeks (arc mercury lamp, 350–1150 nm, 30 mW/cm2, 750 W). Control–intact animals (n = 15). The condition of the animals’ eyes was monitored by ophthalmoscopic and biomicroscopic methods. After 23 weeks, the total antioxidant ( TAA) and oxidative activ- ity ( TOA), the level of fragmented DNA (fDNA), thiol and carboxyl protein groups were determined in the tissues of the cornea, lens and retina of rabbits. Results: Previous studies have established a violation of the redox state of nicotinamide coenzymes in the tissues of the visual analyzer of rabbits un- der the influence of PL. When animals were exposed to PL, an increase in TOA was detected in the cornea by 128 %, in the lens by 137 % (p < 0.05), in the retina by 132 %, carboxyl protein groups by 126 %, 144 % and 136 % (p < 0.05) and fDNA by 124 %, 138 % and 127 % (p < 0.05), respectively, relative to the control. A statistically significant decrease in TAA and the level of thiol protein groups in the studied tissues was established under the influence of PL. Conclusion: The data indicate that prolonged exposure to P L causes oxi- dative modification of biopolymers associated with the processes of oxi- dative and carbonyl stress with depletion of the antioxidant system in the tissues of the eye. Correction of disorders with antioxidants will contrib- ute to the stabilization of the structural and functional properties of the visual analyzer.
  • Тип елементу:Документ,
    Assessing the possibility of using portable and stationary non-mydriatic fundus cameras for diabetic retinopathy screening assisted by an artificial intelligence-based software platform in primary care
    (2025) Невська, Алла Олександрівна; Король, Андрій Ростиславович; Погосян, Ольга Атомівна; Щербакова, Валерія Володимирівна
    Objectives: To assess the possibility of using portable and stationary non- mydriatic (N M) fundus cameras for diabetic retinopathy ( DR) screening as- sisted by the artificial intelligence ( AI)-based Retina- AI CheckEye© soft- ware platform in primary care. Methods: In this prospective, open-label study, 609 subjects (1218 eyes) with either diagnosed diabetes mellitus (D M) or risk factors for D M were divided into two groups depending on whether the fundus camera was stationary or portable. NM single-field fundus photography was per- formed with a stationary fundus camera in group 1 and a portable cam- era in group 2. The AI-b ased Retina- AI CheckEye© software platform was used for the analysis of digital color fundus photographs of subject eyes for signs of D R. The numbers of poor-quality fundus images and the pres- ence or absence of DR were noted, and the stage of DR was assessed. Results: In group 1 and group 2, there were 37 eyes and 339 eyes, respec- tively, whose images could not be processed by the neural network. D R was found in 15 subjects (5.17 %) in group 1 and 8 subjects (2.51 %) in group 2. Previously undiagnosed DM complicated by DR was discovered in 13 (4.5 %) of the subjects included in group 1 versus 7 (2 %) of the sub- jects included in group 2. Conclusions: Digital color fundus images taken with stationary and port- able NM fundus cameras through non-dilated pupils and analyzed by the AI-b ased Retina- AI CheckEye© software platform provided D R detection and grading by stages among subjects with diagnosed DM as well those with undiagnosed D M. The percentage of poor-quality photographs can be reduced and the effectiveness of DR screening with the use of the A I- based Retina- AI CheckEye© software platform can be improved through the involvement of an experienced operator and better adherence to pro- tocol for uploading fundus images to the cloud storage.
  • Тип елементу:Документ,
    Detecting diabetic retinopathy in individuals with objective indicators suggestive of possible undiagnosed diabetes mellitus using an artificial intelligence-based software platform
    (2025) Щербакова, Валерія Володимирівна; Невська, Алла Олександрівна; Погосян, Ольга Атомівна; Король, Андрій Ростиславович
    Objectives: To examine the potential for the detection of diabetic retin- opathy ( DR) using the artificial intelligence ( AI)-based software platform in patients with risk factors of diabetes mellitus. Methods: This was an open-label, prospective, observational case-con- trol study for the detection of DR in patients with risk factors using an AI- based software platform. The study was conducted at the sites of health- care facilities in Chernivtsi region, Lviv region, Kyiv region and Kyiv-city. 5655 individuals (11.310 eyes) were involved in the study. All fundus imag- es were analyzed using the artificial intelligence ( AI)-based software plat- form Retina- AI CheckEye©. Results: All patients were divided into two groups. The first group consist- ed of 1841 patients, who had diabetes mellitus, and the second group had 3814 patients with risk factors of diabetes mellitus. Using the AI- based software platform, in the first group signs of D R were detected in 366 dia- betics (19.88 % of the diabetics). In the second group signs of D R were de- tected in 33 individuals, who had not diabetes mellitus (0.87 % of patients with risk factors). The diagnoses of DR were verified by expert ophthal- mologists in each patient. Conclusions: AI- based software platform, Retina- AI CheckEye© system helps to diagnose the presence of diabetic retinopathy not only in pa- tients with diabetes, but also in patients with risk factors, and can be used for mass screening of the disease. Health care system need to pay more at- tention for patients with risk factors of diabetes mellitus and perform pro- phylactic examinations of the eye fundus.
  • Тип елементу:Документ,
    Effect of the angiotensin-converting enzyme inhibitor zofenopril on nitric oxide metabolism in experimental glaucoma
    (2025) Михейцева, Ірина Миколаївна; Коломійчук, Сергій Григорович; Сироштаненко, Тетяна Іванівна; Алобісі, Маяр; Сторожук, Наталя Віталіївна; Кузнецов, Максим Костянтинович
    Glaucoma is an optic neuropathy, and nitric oxide ( NO) plays an important role as a modulator of autoregulation of blood circulation in the tissues of the optic nerve and retina. Much attention is paid to the role of NO me- tabolism disorders in the development of glaucoma. A new trend is the study of angiotensin-converting enzyme ( ACE) inhibitors as potential anti- glaucomatous agents. Purpose: To study the features of N O metabolism in eye tissues during glaucoma modelling and the use of the ACE inhibitor zofenopril ( ZP). Material and Methods: Adrenaline-induced glaucoma ( AIG) was mod- elled in rabbits by intravenous administration of 0.1 ml of adrenaline solu- tion (1.80 mg/ml) for 3 months (40 injections). Some animals during AIG simulation received zofenopril ( ZP) per os in the form of 1 ml of aqueous suspension (1 mg/kg body weight). The condition of the animals’ eyes was monitored ophthalmoscopically and biomicroscopically. Signs of primary glaucoma with increased intraocular pressure (I OP) were formed in AIG. In the tissues of the eye drainage zone, retina and optic nerve of animals, indicators of N O metabolism were determined: the level of stable N O metabolites (nitrate (NOˉ 3) and nitrite (NOˉ2) anions) and the total activity of constitutive neuronal and endothelial NO- synthases (cNO-synthase). Results: In AIG, a significant decrease in the level of NOˉ3 and NOˉ2 an- ions and the activity of cNO-synthases was found in the tissues of the rabbit eye. The use of ZP in AIG contributed to an increase in the level of NOˉ3-anions in the tissues of the drainage zone by 28.2 %, in the retina by 20.5 %, in the optic nerve of animals by 18.2 %, NOˉ2-anions by 43.0 %, 31.5 % and 22.8 % (p < 0.05), respectively, compared with the data of A IG without treatment. The introduction of Z P suspension against the back- ground of A IG in animals contributed to a significant activation of cNO- synthases in the tissues of the drainage zone by 38.7 %, in the retina by 35.8 % and in the optic nerve by 30.6 % compared to animals with A IG without treatment. Conclusion: The study on AIG show a positive effect of ZP on pathoge- netic links of N O metabolism, which contributed to the reduction of IOP. The obtained experimental data may be a preclinical justification for the feasibility of using zofenopril in the complex therapy of glaucoma in clini- cal conditions.