СОСТОЯНИЕ ВЕГЕТАТИВНОЙ НЕРВНОЙ СИСТЕМЫ ПО ВАРИАБЕЛЬНОСТИ СЕРДЕЧНОГО РИТМА И ЧУВСТВИТЕЛЬНОСТИ Т-ЛИМФОЦИТОВ К НЕЙРОТРАНСМИТТЕРАМ У БОЛЬНЫХ РЕЦИДИВИРУЮЩИМ ИДИОПАТИЧЕСКИМ УВЕИТОМ ПРИ НЕОСЛОЖНЕННОМ И ОСЛОЖНЕННОМ ЕГО ТЕЧЕНИИ В РАЗНЫЕ ПЕРИОДЫ ЗАБОЛЕВАНИЯ

Abstract

Purpose – the assess of the state of the autonomic nervous system (ANS) by the heart rate variability (HRV) and sensitivity of peripheral blood T-lymphocytes to neurotransmitters at patients with recurrent uveitis (RU) with uncomplicated and complicated course RU during different periods of the disease. Material and methods The examination was perfomed in 168 patients with idiopathic RU in relapse and remission and uncomplicated/complicated course. The HRV was examined by the Reocom complex. Specific sensitivity of T-lymphocytes to adrenaline and acetylcholine was perfomed by the complex method for assessing the individual sensitivity to drugs by the method of parallel trials using the immunohistochemical method and monoclonal antibodies. Results The spectral total power of ANS and the LF spectrum (sympathetic nervous system -SNS) increased by 34% and 12.5% respectively in RU relapse. The VLF spectrum (suprasegmental parts of the SNS) decreased by 32% and HF spectrum (parasympathetic parts- PNS) increased by 40.6% at patients with complicated RU. The expression level of T-lymphocytes with adreno/acetylcholine receptors increased at patients with relapse (and by 29% of T-lymphocytes with adrenoreceptors at complicated RU) versus remission stage. A direct correlation relationship was found between VLF, IN (stress index) and indicators of cellular immunity, T-lymphocytes with sensitivity to neurotransmitters and inverse correlation relationship with indicators of humoral immunity (Ig A, Ig G). Conclusion The features of the mutually regulating influence of the ANS and the immune system were revealed at the patients with RAU, depending on the activity of the inflammatory process and complicated course.